Endocrine journal

Changes in Estrogen Receptor Levels in the Rat Uterus During Pregnancy and Labor and Their Possible Role in Controlling Oxytocin Receptors

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Oxytocin receptor (OTR) mRNA levels in the uterus peak at 2200-2230 h on day 21 of pregnancy and during labor.

  • Estrogen is believed to enhance OTR mRNA expression, but it does not stimulate expression in rat on day 18 of pregnancy or in progesterone-treated rats.
  • Uterine responsiveness to estrogen appears to be a key factor in regulating OTR induction.
  • ERalpha mRNA levels significantly increase during labor compared to earlier days of pregnancy.
  • In ovariectomized virgin rats given progesterone, ERalpha mRNA levels decrease but return to control levels after progesterone removal.
  • Estrogen treatment on day 18 of pregnancy raises OTR mRNA levels, while ovariectomy increases ERbeta mRNA but not ERalpha mRNA.
  • The study suggests that ERalpha may play a more significant role than ERbeta in the regulation of OTR mRNA during labor.

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