Differential Regulation of Estrogen Receptor .ALPHA. and .BETA. mRNAs in the Rat Uterus during Pregnancy and Labor: Possible Involvement of Estrogen Receptors in Oxytocin Receptor Regulation

Nov 14, 2003Endocrine journal

Changes in Estrogen Receptor Levels in the Rat Uterus During Pregnancy and Labor and Their Possible Role in Controlling Oxytocin Receptors

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Abstract

Oxytocin receptor (OTR) mRNA levels in the uterus peak at 2200-2230 h on day 21 of pregnancy and during labor.

  • Estrogen is believed to enhance OTR mRNA expression, but it does not stimulate expression in rat on day 18 of pregnancy or in progesterone-treated rats.
  • Uterine responsiveness to estrogen appears to be a key factor in regulating OTR induction.
  • ERalpha mRNA levels significantly increase during labor compared to earlier days of pregnancy.
  • In ovariectomized virgin rats given progesterone, ERalpha mRNA levels decrease but return to control levels after progesterone removal.
  • Estrogen treatment on day 18 of pregnancy raises OTR mRNA levels, while ovariectomy increases ERbeta mRNA but not ERalpha mRNA.
  • The study suggests that ERalpha may play a more significant role than ERbeta in the regulation of OTR mRNA during labor.

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