Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Finding the ETH receptor and its possible functions in the mud crab

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

A 16-day administration of Ecdysis-triggering hormone (SpETH) significantly increased gonadosomatic index and oocyte size in the mud crab Scylla paramamosain.

  • A G protein-coupled receptor for SpETH (SpETHR) was identified in S. paramamosain and activated by SpETH with an EC value of 75.18 nM.
  • SpETH was found in the cerebral and thoracic ganglia, while SpETHR was specifically expressed in the ovary, hepatopancreas, and Y-organ of female crabs.
  • In vitro, synthetic SpETH at 10 µM increased the expression of the vitellogenin receptor (SpVgR) in the ovary and induced ecdysone production in the Y-organ.
  • In vivo, SpETH injection led to significant upregulation of ecdysone receptor (SpEcR) in the ovary and other developmental factors in the Y-organ.
  • SpETH administration is associated with increased 20-hydroxyecdysone levels in hemolymph, indicating potential involvement in ovarian development.

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Competing interests

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PubMed

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