Evening was associated with a higher odds ratio of 1.06 for migraine diagnosis compared to morning type controls.
Migraine patients with an evening chronotype reported worse mental and physical health compared to morning type controls.
The evening type migraine group exhibited a higher level of disability related to headaches.
Both morning and evening type migraine patients displayed similar headache symptoms.
The analysis involved a large sample from the UK Biobank, including 360,081 participants.
Simplified
Migraine has been linked to , but with mixed results. Here, we tested chronotype in association with physical and mental health and headache characteristics in a large database of migraine patients and controls. A sample of the UK Biobank (n = 360,081; 58.3% female, mean age: 56.38) was used. Data included self-reported chronotype, mental (neuroticism, depression, stress) and physical (body fat percentage, overall health rating) health factors, and migraine diagnosis based on ICD-10 G43 diagnosis from healthcare data. Morning type controls (C, n = 210,775), evening type controls (C, n = 129,174), morning type migraine patients (M, n = 12,194), and evening type migraine patients (M, n = 7938) were compared. Additionally, in a subsample of questionnaire-based migraine (n = 15,356), chronotype was tested in association with headache-related features. One-way ANOVA, Kruskal-Wallis test and chi-squared test were run in SPSS 28 with Bonferroni correction. Evening chronotype was more frequent among migraine patients with an OR = 1.06, 95% CI [1.03; 1.09] compared to controls (χ = 16.523, p < 0.001). The Mgroup showed the worst level of all mental and physical health variables, while the Cgroup reported the best values. Migraine patients with morning or evening chronotype showed a highly similar headache symptom profile, but the Msubgroup expressed a higher disability (t = -3.965, p < 0.001). In conclusion, evening chronotype was associated with the worst physical and mental health status and the highest headache-related disability among migraine patients, suggesting a need for elevated medical attention on chronotype in migraine. morning evening morning evening evening morning evening2
Key numbers
1.06
Odds of Evening
Odds ratio comparing evening in migraine patients vs. controls.
t = -3.965
Headache-Related Disability Increase
Statistical comparison of headache-related disability between .
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Preliminary results were presented at PhD Scientific Days, Semmelweis University, 22–23 June 2023, Budapest (lecture), and at the 7th European Congress of NeuroRehabilitation, 30 August–2 September 2023, Lyon, hybrid (poster presentation)—a related abstract was published in NEUROLOGIE UND REHABILITATION 29: S1 p. S125 Paper: P192 (2023). G.B. is a member of the Board of Directors at Gedeon Richter, but the company did not provide any funding or have any further role in the preparation of this article. All other authors declare no conflicts of interest.
