Different roles of two neuropeptide-Y receptors in daily control of movement, exploration, drinking, and eating in mice without these receptors

Y2-/- and Y4-/- mice exhibited distinct patterns of behavior and weight compared to wild-type mice.

• Y2-/- mice showed reduced diurnal locomotion, exploration, drinking, and feeding, while nocturnal locomotion was enhanced.
• Y4-/- mice displayed increased movement but reduced eating and drinking during daylight hours, and higher food intake but less exploration at night.
• Both Y2-/- and Y4-/- mice had greater body weights than wild-type mice.
• The findings suggest different roles for Y2 and Y4 receptors in managing energy intake and expenditure across the circadian cycle.
• Behavioral changes in mice were continuously monitored using the LabMaster system, indicating its effectiveness for such analyses.

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