We can’t show the full text here under this license.
A Glucagon-Like Peptide-1 Receptor Activator Reduces Food Intake by Acting on Appetite-Control Neurons in the Brain
Updated
Abstract
The appetite-suppressing effects of Ex-4c are mediated through the activation of neurons.
- Ex-4c activates pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
- Fos immunochemistry and whole-cell patch-clamp recordings confirmed the activation of POMC neurons by Ex-4c.
- Ex-4c stimulates GLP-1 receptors and activates a signaling pathway that involves protein kinase A (PKA).
- The PKA-dependent signaling leads to the closure of KATP channels, resulting in depolarization of POMC neurons.
Simplified
Key numbers
0.32 μg
Median Effective Dose for Food Intake Suppression
Dose of Ex-4c required for significant food intake reduction.
242±10
Neuron Count Post-Ablation
Average number of β-endorphin positive neurons in iDTR::-Cre mice.