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Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria
Exercise hormone irisin may ease rheumatoid arthritis by clearing damaged cell energy parts
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Abstract
Irisin may interact with integrin subunits to activate mitophagy, contributing to reduced inflammation in arthritis models.
- Irisin is associated with therapeutic effects in two mouse models of rheumatoid arthritis: K/BxN serum and collagen-induced arthritis.
- The mechanism involves irisin activating processes that eliminate damaged mitochondrial components and reactive molecules.
- Activation of mitophagy by irisin leads to suppression of the NLRP3 inflammasome, which is linked to inflammation in arthritis.
- The beneficial effects of irisin were significantly diminished in mice lacking a specific gene related to cellular cleanup in immune cells.
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