BoneApr 11, 2025

Exercise helps reduce osteoporosis by controlling harmful substances released by aging cells

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 29, 2026

Abstract

Exercise is recognized for its cost-effectiveness and safety in managing osteoporosis.

The elderly population is increasingly affected by metabolic bone diseases, particularly osteoporosis.
Pharmacological therapies for osteoporosis, while beneficial, can lead to adverse effects with prolonged use.
Exercise may improve metabolic bone diseases by influencing the Senescent Associated Secretory Phenotype (SASP).
The specific mechanisms by which exercise regulates SASP and its effects on osteoporosis are not fully understood.
This review aims to clarify how exercise affects SASP to support osteoporosis management and inform targeted therapies.

Simplified

As the elderly population grows, the number of patients with metabolic bone diseases such as osteoporosis has increased sharply, posing a significant threat to public health and social economics. Although pharmacological therapies for osteoporosis demonstrate therapeutic benefits, their prolonged use is associated with varying degrees of adverse effects. As a non-pharmacological intervention, exercise is widely recognized for its cost-effectiveness, safety, and lack of toxic side effects, making it a recommended treatment for osteoporosis prevention and management. Previous studies have demonstrated that exercise can improve metabolic bone diseases by modulating the Senescent Associated Secretory Phenotype (SASP). However, the mechanisms through which exercise influences SASP remain unclear. Therefore, this review aims to summarize the effects of exercise on SASP and elucidate the specific mechanisms by which exercise regulates SASP to alleviate osteoporosis, providing a theoretical basis for osteoporosis through exercise and developing targeted therapies.

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

PubMed

Exercise helps reduce osteoporosis by controlling harmful substances released by aging cells

Abstract

Full Text

Funding

Competing interests

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Abstract

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