Full text is available at the source.
Abstract
Highly-expanded konjac fiber significantly delayed gastric emptying and inhibited chyme hydrolysis.
- Konjac fiber, particularly the highly-expanded version, increased short-chain fatty acid levels and plasma glucagon-like peptide-1 (GLP-1) levels.
- The expression of GLP-1 receptor protein was upregulated in the stomach and specific brain areas of rats.
- There was a down-regulation of appetite-related genes AgRP/NPY in the hypothalamus, which is associated with reduced appetite.
- Daily food intake and weight gain were inhibited in rats consuming konjac fiber.
- The study highlights the role of expandable konjac fiber in regulating appetite and chyme digestion through the stomach-intestine-brain axis.
Simplified