Frontiers in pharmacologyOct 30, 2026

GLP-1 drugs and DPP-4 inhibitors linked to memory loss in older adults with type 2 diabetes

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Nov 2, 2026

Abstract

Older adults with type 2 diabetes may experience an increased risk of cognitive decline.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are associated with neuroprotective effects.
Comparative evidence of GLP-1RAs versus dipeptidyl peptidase-4 inhibitors (DPP-4i) in older adults is limited.
Understanding the effects of these treatments on cognitive health in older populations is necessary.

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