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FAM109B plays a tumorigenic role in low-grade gliomas and is associated with tumor-associated macrophages (TAMs)
FAM109B may promote tumor growth in low-grade brain tumors and is linked to immune cells in the tumor
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Abstract
FAM109B expression is significantly elevated in various tumor types, including low-grade gliomas, and is associated with poor prognosis.
- FAM109B serves as an independent prognostic marker for low-grade glioma patients.
- Increased levels of FAM109B correlate with aggressive tumor progression and poor patient outcomes.
- Lower levels of DNA promoter methylation of FAM109B are associated with higher glioma grades.
- FAM109B is significantly expressed in within the tumor microenvironment.
- Expression of FAM109B is linked to gene mutations, immune checkpoints, and sensitivity to chemotherapy in low-grade gliomas.
- In vivo experiments indicate that reduced FAM109B expression slows tumor growth and extends survival in mouse models.
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Key numbers
1.659
Independent Prognostic Factor Hazard Ratio
Cox regression analysis in TCGA dataset.
0.846
AUC for 1-year OS prediction
ROC curve analysis in TCGA dataset.
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FAM109B expression in LGG vs. normal tissues
Comparison of FAM109B levels using qRT-PCR.