From fat to fate: how aging adipose tissue drives systemic metabolic aging

Aging adipose tissue may contribute to metabolic disorders.

• Aging adipose tissue acts as an 'amplifier' for systemic metabolic issues.
• It alters the environment of other organs through its secretions.
• This may connect obesity, diabetes, heart disease, and brain disorders.
• Senescent adipocytes play a key role in these metabolic dysfunctions.
• Potential interventions include activating thermogenesis and eliminating senescent cells.
• These strategies could help delay aging and related metabolic diseases.

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