The FATP1-DGAT2 complex helps fat droplets grow where they form in cells

FATP1 and DGAT2 are components of a triglyceride synthesis complex that may facilitate lipid droplet expansion.

• The interaction between FATP1 and DGAT2 is crucial for lipid droplet expansion in Caenorhabditis elegans.
• A loss of function in either FATP1 or DGAT2 resulted in blocked lipid droplet expansion.
• FATP1 preferentially associates with DGAT2, and both proteins work together to promote lipid droplet expansion in mammalian cells.
• Live imaging shows that FATP1 and DGAT2 are located in the endoplasmic reticulum and lipid droplets, respectively.
• Electron microscopy revealed FATP1 and DGAT2 close to the lipid droplet surface.
• DGAT2 that remains in the endoplasmic reticulum does not support lipid droplet expansion.

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