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Abstract
Short-chain fatty acids generated by gut microbiota may regulate neuroinflammation and blood-brain barrier integrity.
- Fatty acids (FAs) have diverse roles in neurodegenerative diseases like Alzheimer's and Parkinson's.
- Short-chain FAs influence gut-brain communication and immune responses through epigenetic changes.
- Medium-chain FAs may enhance energy metabolism and neuromuscular function in models of amyotrophic lateral sclerosis.
- Long-chain polyunsaturated fatty acids, such as DHA and EPA, support neuronal health by maintaining membrane integrity and reducing oxidative stress.
- Certain saturated and n-6 fatty acids could worsen neurodegeneration by promoting inflammation and oxidative damage.
- Fatty acids are implicated in critical pathological processes including mitochondrial dysfunction and blood-brain barrier disruption.
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