Gut bacteria from women with polycystic ovary syndrome cause metabolism and ovary problems in mice without microbes

Mice receiving fecal microbiota from PCOS patients exhibited distinct bacterial profiles and significant reproductive endocrine changes.

• Fecal microbiota from PCOS patients was enriched in specific bacteria such as Phocaeicola and Mediterraneibacter.
• Transplanted mice showed increased disruption in ovarian function compared to those receiving microbiota from healthy controls.
• Lipo-metabolic disturbances and insulin resistance were observed in recipient mice with PCOS-associated microbiota.
• An obese-like phenotype developed in mice after fecal microbiota transplantation from PCOS patients.
• The findings indicate a potential link between the gut microbiome and the pathogenesis of PCOS.

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