Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life

May 23, 2020Open access rheumatology : research and reviews

Fibromyalgia with Knee Osteoarthritis and Its Possible Impact on Movement and Quality of Life

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Abstract

was diagnosed in 35.5% of patients.

Patients with both knee osteoarthritis and fibromyalgia experienced higher pain levels and lower quality of life compared to those with knee osteoarthritis only.
Significant correlations were found between pain levels and factors such as body mass index, functional impairment, anxiety, and depression.
A higher score on the Pain Anxiety Symptom Scale was identified as a predictor of lower quality of life in patients with knee osteoarthritis and fibromyalgia.

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BACKGROUND: (OA) is a painful condition with peripheral and central pain transmission. (FM) is the role model of central sensitization of pain perception.

AIM: To assess the frequency of FM in knee OA patients and evaluate the impact of FM on mental health and the quality of life in knee OA patients.

PATIENTS AND METHODS: A total of 121 female patients were recruited and divided into 3 groups: group I of 59 patients with knee OA only, group II of 32 patients with knee OA and FM, and group III of 30 FM patients. Patients underwent history taking, examination, investigations, and radiological evaluation of both knees. The assessment of visual analog scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Pain Anxiety Symptom Scale Short Form 20 (PASS20), Beck Depression Inventory (BDI-II), and PCASEE questionnaire were done for all patients. Lequesne index of knee OA and radiological Kellgren and Lawrence score severity were done for all OA patients. Fibromyalgia Impact Questionnaire (FIQ) was assessed for all FM patients.

RESULTS: FM was diagnosed in 35.5% of knee OA patients. Group II patients had higher VAS, PASS-20, PSQI, and lower quality of life than either groups I and III, elevated Lequesne index score than group I, significant correlation between VAS and BMI (p=0.002), Lequesne index score (p<0.001), PASS20 (p=0.006), BDI-II score (p=0.002), and FIQ (P<0.001), and a negative correlation was found between VAS and physical (p<0.001), anxiety (p=0.046), and social (p=0.026) QoL parameters. Univariable regression analysis showed a higher age, VAS, PSQI, PASS20, and FIQ were associated with lower QoL in group II. A higher PASS20 was the only predictor of lower QoL in multivariable analysis.

CONCLUSION: Fibromyalgia coexists frequently in knee OA patients and has implications on their mental health, functional activity, and quality of life.

Key numbers

35.5%

Prevalence of in Knee Patients

Percentage of knee patients diagnosed with

0.002

Quality of Life Comparison

P-value for quality of life differences between groups

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Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life

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