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Identification of Flavin Mononucleotide as a Cell‐Active Artificial N6‐Methyladenosine RNA Demethylase
Discovery of Flavin Mononucleotide as an Artificial Molecule That Removes RNA Methylation Inside Cells
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Abstract
Flavin mononucleotide (FMN) mediates substantial photochemical demethylation of mA residues in RNA in live cells.
- N-Methyladenosine (mA) is a common modification in eukaryotic RNA that influences various cellular pathways.
- FTO and ALKBH5 are natural enzymes that remove mA residues from mRNA.
- The identification of FMN as an artificial mA demethylase represents a significant advancement.
- This discovery provides new insights into the demethylation processes of mA in mRNA.
- FMN could serve as a powerful tool for probing RNA biology.
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