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Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
Flavin-containing monooxygenase 3 influences blood sugar, fat metabolism, and artery disease
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Abstract
Knockdown of hepatic FMO3 in LDL receptor knockout mice resulted in decreased circulating TMAO levels and atherosclerosis.
- Decreased hepatic FMO3 led to reduced levels of circulating TMAO and atherosclerosis in hyperlipidemic mouse models.
- Significant decreases in hepatic lipids, plasma lipids, ketone bodies, glucose, and insulin were observed following FMO3 knockdown.
- Overexpression of FMO3 in transgenic mice resulted in increased hepatic and plasma lipids.
- Global gene expression analyses indicated that FMO3's effects on fat and sugar metabolism may involve specific biological pathways.
- Increased glucose secretion and lipogenesis were noted in human liver cells when FMO3 was overexpressed.
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