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Abstract
Sleep deprivation may induce cognitive impairment associated with gut microbiota dysbiosis, which can be mitigated by flavonoid-rich Ficus pandurata angustifolia.
- Flavonoid-rich Ficus pandurata angustifolia (FCF) alleviated cognitive deficits in a sleep-deprived mouse model.
- FCF reversed gut microbiota dysbiosis by increasing beneficial bacteria and reducing harmful ones.
- Production of short-chain fatty acids was promoted by FCF treatment.
- FCF improved colonic histopathology and intestinal barrier function.
- Serum lipopolysaccharide levels were reduced, indicating decreased gut permeability.
- Neuroinflammation was suppressed by inhibiting glial cell activation and TLR4/NF-κB signaling.
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