Nuclear medicine communicationsAug 20, 2026

Whole-body glucose metabolism imaging in people with long COVID: the ERASE-LC trial plan

Updated Aug 21, 2026

Abstract

The ERASE-LC trial aims to recruit 72 participants to assess the feasibility of remdesivir for treating long COVID.

PET/computed tomography scans will be conducted at baseline (day 11) and follow-up (day 55) for 20 participants.
The estimated effective radiation dose for the scans is approximately 22 mSv, with a maximum anticipated exposure of 31.2 mSv.
Dynamic scans will utilize the FlowMotion acquisition method on a Siemens Biograph Vision 600 scanner for 75-90 minutes.
Preliminary experiences indicate that participants tolerated the scan duration and positioning.
This protocol represents a novel application of whole body scans to evaluate long COVID and treatment response.

Simplified

The ERASE-LC feasibility trial will evaluate the feasibility of using remdesivir for the treatment of long coronavirus disease (COVID) with a wide range of outcome measures. This paper focuses on the nested parametric PET/computed tomography study and outlines the novel protocol utilized. The PET/computed tomography scans will be performed at one of the sites in 20 participants with an overall recruitment target of 72 participants across both centers. The PET/computed tomography scans will be performed at day 11 for the baseline scan and day 55 for the follow-up scan, with an estimated effective radiation dose of approximately 22 mSv under typical study conditions and a maximum anticipated exposure of 31.2 mSv. Dynamic scans will be acquired using the FlowMotion acquisition on a Siemens Biograph Vision 600 scanner with an acquisition time of 75-90 min depending on the height of the participant. Patient and public involvement and engagement was undertaken throughout the study design. The early experiences of performing this protocol demonstrated that participants were able to tolerate the scan duration and positioning. In conclusion, this protocol demonstrates a novel use of parametric PET/computed tomography fluorine-18 fluorodeoxyglucose whole body scans for the assessment of long COVID and response to remdesivir.

Full Text

Full text is available at the source.

View Full Text ↗

Whole-body glucose metabolism imaging in people with long COVID: the ERASE-LC trial plan

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the long covid brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the long covid brief