Fluorine-a small magic bullet atom in the drug development: perspective to FDA approved and COVID-19 recommended drugs

Jun 26, 2023Chemicke zvesti

Fluorine’s important role in approved medicines and COVID-19 treatments

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Abstract

Ten fluorinated drugs were approved by the FDA in 2021.

Fluorinated drugs have become an essential component of modern pharmaceuticals, with a growing presence in the market each year.
During the COVID-19 pandemic, fluorinated drugs played a crucial role in managing the disease.
Among the approved drugs in 2021, pylarify was recognized as a radioactive diagnostic agent for cancer imaging.
The review highlights the synthesis, medicinal chemistry, and development processes of fluorinated drugs.
Fluorinated drugs are associated with unique physical and chemical properties that enhance their effectiveness in drug development.

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During the last twenty years, organic fluorination chemistry established itself as an important tool to get a biologically active compound. This belief can be supported by the fact that every year, we are getting fluorinated drugs in the market in extremely significant numbers. Last year, also ten fluorinated drugs have been approved by FDA and during the COVID-19 pandemic, fluorinated drugs played a very crucial role to control the disease and saved many lives. In this review, we surveyed all ten fluorinated drugs approved by FDA in 2021 and all fluorinated drugs which were directly-indirectly used during the COVID-19 period, and emphasis has been given particularly to their synthesis, medicinal chemistry, and development process. Out of ten approved drugs, one drug pylarify, a radioactive diagnostic agent for cancer was approved for use in positron emission tomography imaging. Also, very briefly outlined the significance of fluorinated drugs through their physical, and chemical properties and their effect on drug development.

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Fluorine-a small magic bullet atom in the drug development: perspective to FDA approved and COVID-19 recommended drugs

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