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A review: FDA-approved fluorine-containing small molecules from 2015 to 2022
Overview of FDA-approved small fluorine-containing drugs from 2015 to 2022
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Abstract
Over the last 50 years, numerous fluorinated compounds have been approved for clinical use.
- Fluorinated corticosteroids and fluoroquinolones were successfully used in the 1950s and 1980s, respectively.
- Fluorinated compounds exhibit diverse biological properties, including antitumor, antimicrobial, and anti-inflammatory activities.
- The design of fluorinated pharmaceuticals benefits from enhanced potency and favorable absorption, distribution, metabolism, and excretion characteristics.
- A review of approved fluorinated drugs from 2015 to 2022 was conducted.
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