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Free-choice high-fat diet alters circadian oscillation of energy intake in adolescent mice: role of prefrontal cortex
High-fat diet changes daily patterns of eating in teen mice, involving the thinking part of the brain
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Abstract
Mice with free access to a high-fat diet (HFD) consumed less energy and gained less body weight compared to those on a non-optional HFD over 48 hours.
- Mice on the free choice HFD protocol avoided standard chow, leading to lower energy intake.
- All mice with access to HFD showed nocturnal overeating, with the free choice group exhibiting more pronounced daytime hyperphagia.
- Tyrosine hydroxylase gene expression increased significantly during the light period in mice with free access to HFD.
- Both feeding protocols equally up-regulated the expression of cytosolic malic enzyme, which is sensitive to high-fat diets.
- The findings suggest that the prefrontal cortex may influence feeding motivation during episodes of high-fat diet-induced overeating.
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