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Restricting feeding to the active phase in middle-aged mice attenuates adverse metabolic effects of a high-fat diet
Limiting eating to active times reduces harmful metabolism effects of a high-fat diet in middle-aged mice
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Abstract
HFD-TRF mice gained significantly less weight than HFD-AL mice, with approximately 20% vs 55% of initial weight, respectively.
- Time-restricted feeding (TRF) allowed HFD mice to only eat for 8 hours per day during their active period.
- Caloric intake differences between HFD-TRF and HFD-AL mice were mostly observed during the first 8 weeks.
- TRF of a high-fat diet improved glucose tolerance as indicated by lower incremental area under the curve (iAUC) compared to low-fat diet mice.
- TRF significantly reduced liver weight in HFD mice, but did not affect fat pad weights.
- Neither HFD-AL nor HFD-TRF mice showed differences in memory performance on cognitive tests.
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