Meal pattern alterations associated with intermittent fasting for weight loss are normalized after high-fat diet re-feeding

After 4 weeks of alternate day intermittent fasting, all groups lost weight compared to those on a high-fat diet.

• Mice on alternate day intermittent fasting had larger first meal sizes and faster eating rates compared to those on a continuous high-fat diet at Day 2.
• At Day 28, intermittent fasting groups continued to show greater first meal sizes and faster eating rates than their respective ad libitum fed groups.
• Meal duration was longer in low-fat diet groups compared to high-fat diet groups at the end of the diet period.
• After 6 weeks of re-feeding on a high-fat diet, there were no differences in meal patterns between groups that had undergone intermittent fasting and those that had not.
• These results indicate that changes in meal patterns associated with intermittent fasting are temporary.

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