Time-restricted feeding reduces adiposity in mice fed a high-fat diet

Time-restricted feeding for 8 hours during the dark cycle reduced body fat mass and body weight in mice fed a high-fat diet.

• Time-restricted feeding did not significantly alter energy intake compared to ad libitum feeding.
• Mice on time-restricted feeding showed reduced body fat mass and weight compared to those fed a high-fat diet ad libitum.
• Respiratory exchange ratios were lower in both time-restricted and high-fat ad libitum groups compared to the control group on a standard diet.
• Energy expenditure was slightly lower in the time-restricted feeding groups compared to the ad libitum group on a high-fat diet.
• Plasma concentrations of ghrelin increased in time-restricted feeding groups compared to both the control and ad libitum high-fat diet groups.
• Time-restricted feeding reduced elevated plasma levels of insulin, leptin, and certain inflammatory markers associated with high-fat diet consumption.

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