Time-restricted feeding of a high-fat diet in male C57BL/6 mice reduces adiposity but does not protect against increased systemic inflammation

May 3, 2018Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Limited daily eating of a high-fat diet lowers body fat but does not reduce overall inflammation in male mice

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Time-restricted feeding (TRF) reduced weight gain in mice on a high-fat diet over an 8-week period.

TRF limited food access to 6 hours per day led to decreased weight gain compared to unrestricted feeding.
Body fat percentage, liver triglycerides, and plasma leptin and cholesterol levels were reduced in TRF mice.
Adipose tissue inflammation was lower in both TRF groups, as indicated by reduced macrophage infiltration.
The group with late food access gained more weight and exhibited increased insulin resistance compared to the early access group.
Increased systemic inflammatory markers were noted in all high-fat diet groups, suggesting diet components may contribute to inflammation regardless of obesity.

AI simplified

Time-restricted feeding (TRF) limits the duration of food availability without altering diet composition and can combat obesity in humans and mice. For this study we evaluated the effect of timing of food access during a TRF protocol on weight gain, adiposity, and inflammation. Young male C57BL/6 mice were placed on a high-fat (HF) diet (45% fat) for 8 weeks. Food access was unrestricted (HF) or restricted to 6 h per day, either for the first half (HF-early) or the second half (HF-late) of the active phase to resemble a window of time for food consumption early or late in the day in a human population. Weight, obesity-associated parameters, and inflammation were measured. TRF reduced weight gain over the 8-week period in mice consuming the same high-fat diet. Consistent with decreased weight gain in the TRF groups, body fat percentage, liver triglycerides, and plasma leptin and cholesterol levels were reduced. Adipose tissue inflammation, measured by CD11bF4/80macrophage infiltration, was reduced in both TRF groups, but systemic tumor necrosis factor-α was increased in all groups consuming the high-fat diet. The HF-late group gained more weight than the HF-early group and had increased insulin resistance, while the HF-early group was protected. Therefore, a TRF protocol is beneficial for weight management when a high-fat diet is consumed, with food consumption earlier in the day showing greater health benefits. However, increased inflammatory markers in the TRF groups suggest that diet components can still increase inflammation even in the absence of overt obesity. + +

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Time-restricted feeding of a high-fat diet in male C57BL/6 mice reduces adiposity but does not protect against increased systemic inflammation

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief