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Time-restricted Feeding Attenuates High-fat Diet-enhanced Spontaneous Metastasis of Lewis Lung Carcinoma in Mice
Limiting Eating Times Reduces High-fat Diet-Driven Spread of Lung Cancer in Mice
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Abstract
Time-restricted feeding (TRF) may prevent obesity-related increases in lung metastases in mice.
- Mice on a high-fat diet (HFD) had greater numbers and sizes of lung metastases compared to those on a standard diet.
- There were no significant differences in lung metastases between the TRF and standard diet groups.
- TRF was associated with lower plasma levels of glucose, insulin, and several proinflammatory and angiogenic factors compared to the HFD group.
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