Time-restricted feeding mitigates high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice

The high-fat diet group had 24% more body fat mass than the standard diet group.

• Time-restricted feeding during the dark phase did not increase mammary tumor growth compared to the standard diet.
• Mammary tumor progression was 241% higher in the high-fat diet group compared to the standard diet group.
• The median time until mammary tumors appeared was similar across the high-fat diet and restricted groups, at 6.4 and 7.0 weeks, respectively.
• Plasma levels of several inflammatory and growth-related proteins were significantly higher in the high-fat diet group compared to the standard diet group, but similar between the restricted and standard diet groups.
• The findings suggest that dark phase feeding could counteract the tumor-promoting effects of a high-fat diet, potentially due to lower body fat and inflammation.

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