Long-term voluntary running improves diet-induced adiposity in young adult mice

Running reduced adiposity by percentage fat body mass in young adult mice fed a high-fat diet.

• The high-fat diet increased percentage fat body mass compared to a standard diet.
• Running significantly decreased percentage fat body mass and increased percentage lean body mass in mice on both diets.
• Sedentary mice on the high-fat diet showed elevated plasma insulin and leptin concentrations.
• Running lowered plasma insulin and leptin levels, and reduced inflammatory cytokine MCP-1 in mice fed the high-fat diet.
• Running increased plasma vascular endothelial growth factor regardless of the diet consumed.

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