Eating only during limited times without cutting calories prevents metabolic diseases in mice on a high-fat diet

Mice subjected to time-restricted feeding (tRF) for 8 hours daily showed protection against obesity and its related metabolic diseases despite consuming equivalent calories from a high-fat diet.

• Time-restricted feeding may disrupt the normal feeding cycle and prevent obesity, hyperinsulinemia, and liver inflammation.
• Mice under tRF exhibited improved motor coordination compared to those with ad lib access to food.
• The tRF regimen is associated with enhanced function of metabolic pathways such as CREB, mTOR, and AMPK.
• Circadian clock oscillations and expression of target genes improved under the tRF regimen.
• Changes in catabolic and anabolic pathways altered the liver's metabolome and enhanced energy expenditure.

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