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Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Eating only during limited times without cutting calories prevents metabolic diseases in mice on a high-fat diet
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Abstract
Mice subjected to time-restricted feeding (tRF) for 8 hours daily showed protection against obesity and its related metabolic diseases despite consuming equivalent calories from a high-fat diet.
- Time-restricted feeding may disrupt the normal feeding cycle and prevent obesity, hyperinsulinemia, and liver inflammation.
- Mice under tRF exhibited improved motor coordination compared to those with ad lib access to food.
- The tRF regimen is associated with enhanced function of metabolic pathways such as CREB, mTOR, and AMPK.
- Circadian clock oscillations and expression of target genes improved under the tRF regimen.
- Changes in catabolic and anabolic pathways altered the liver's metabolome and enhanced energy expenditure.
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