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Effect of Aerobic Exercise and Time‐Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High‐Fat Diet
How Aerobic Exercise and Time-Restricted Feeding Affect Metabolism and Body Clock in Mice on a High-Fat Diet
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Abstract
High-fat diet feeding disrupted clock genes in peripheral organs, while time-restricted feeding and exercise restored them.
- Time-restricted feeding (tRF) combined with exercise significantly decreased body weight, food intake, and plasma lipids.
- Both tRF and tRF-exercise improved glucose tolerance in mice fed a high-fat diet.
- Exercise alone reduced body weight and plasma lipids, but did not improve glucose tolerance.
- tRF and tRF-exercise downregulated specific genes associated with fat and cholesterol metabolism, while exercise only affected one of these genes.
- High-fat diet feeding disrupted circadian clock genes, but exercise, tRF, and their combination coordinated the regulation of these genes in various tissues.
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