How Aerobic Exercise and Time-Restricted Feeding Affect Metabolism and Body Clock in Mice on a High-Fat Diet

High-fat diet feeding disrupted clock genes in peripheral organs, while time-restricted feeding and exercise restored them.

• Time-restricted feeding (tRF) combined with exercise significantly decreased body weight, food intake, and plasma lipids.
• Both tRF and tRF-exercise improved glucose tolerance in mice fed a high-fat diet.
• Exercise alone reduced body weight and plasma lipids, but did not improve glucose tolerance.
• tRF and tRF-exercise downregulated specific genes associated with fat and cholesterol metabolism, while exercise only affected one of these genes.
• High-fat diet feeding disrupted circadian clock genes, but exercise, tRF, and their combination coordinated the regulation of these genes in various tissues.

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