Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

Time-restricted feeding (TRF) may protect circadian clock mutant mice from obesity and metabolic diseases.

• Circadian clock mutant mice gained weight and exhibited metabolic defects when allowed to eat freely.
• TRF, restricting food access to 10 hours during the dark phase, prevented excessive weight gain in these mice.
• Metabolomic and transcriptomic analyses indicated that TRF reduced liver lipid accumulation.
• TRF appeared to enhance the mice's defenses against metabolic stress.
• The findings suggest that the circadian clock plays a role in metabolic homeostasis by promoting regular feeding and fasting patterns.

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