Effects of a free-choice high-fat high-sugar diet on brain PER2 and BMAL1 protein expression in mice

A free choice high-fat high-sugar diet leads to increased calorie intake and body weight gain in mice.

• Rats on a high-fat high-sugar diet showed a similar sugar intake during both day and night phases.
• Regular chow intake maintained a rhythmic pattern despite the altered sugar consumption.
• The high-fat high-sugar diet may disrupt the coordination of feeding rhythms regulated by brain circadian oscillators.
• In the lateral habenula, the day-night difference in clock protein expression was altered in mice exposed to the high-fat high-sugar diet compared to control mice.
• These findings support previous results in rats regarding disrupted feeding behavior patterns under high-fat high-sugar diet conditions.

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