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Frequent Shifts During Chronic Jet Lag Uncouple Liver Rhythms From the Light Cycle in Male Mice
Frequent Time Zone Changes During Long-Term Jet Lag Disrupt Liver Rhythms from the Light-Dark Cycle in Male Mice
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Abstract
More frequent 8-hour forward shifts in light schedules led to more severe misalignment and non-fasted hyperglycemia.
- paradigms are used to study the effects of circadian disruption on health.
- Neither of the tested jet lag paradigms induced arrhythmicity in liver function.
- Distinct effects on rhythmicity were observed between the two chronic jet lag paradigms.
- Shifts every other day caused a separation between behavioral and liver rhythms from the light cycle.
- Misalignment, rather than a lack of rhythm, may be the primary issue linked to metabolic dysfunction in circadian disruption.
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Key numbers
17.5%
Increase in Blood Glucose (Dark Phase)
Blood glucose increase in during the dark phase.
38.9%
Increase in Blood Glucose (Light Phase)
Blood glucose increase in during the light phase.
32.76%
Decrease in Fat-to-Lean Mass Ratio
Fat-to-lean mass ratio decrease in .