Preventive Effect of L-Carnitine on the Disorder of Lipid Metabolism and Circadian Clock of Mice Subjected to Chronic Jet-Lag

Jul 22, 2017Physiological research

L-carnitine may prevent fat metabolism and body clock problems in mice with long-term jet lag

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Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

L-Carnitine administration significantly decreased levels of serum glutamic-oxaloacetic transaminase (GOT) and triglycerides (TG) in mice subjected to chronic jet-lag.

  • Chronic jet-lag induced by reversing light/dark cycles every 4 days for 12 weeks elevated serum GOT and triglycerides in mice.
  • L-Carnitine administration may counteract these elevated levels associated with chronic circadian disruption.
  • Supplementation with L-Carnitine is linked to improved gene expression related to lipid metabolism and circadian rhythms in the liver.
  • Key genes affected include those involved in lipid metabolism (Srebp1, Acaca, Fasn, Scd1) and circadian rhythm (Bmal1, Per1, Cry1, Dec1).
  • Findings suggest that L-Carnitine may help mitigate metabolic disorders related to circadian rhythm disruption.

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