Proceedings of the National Academy of Sciences of the United States of America

How the stability of a key clock protein relates to temperature balance in Neurospora's daily rhythm

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Experimental findings show that the stability of the FRQ protein is crucial for the temperature compensation of Neurospora crassa's circadian rhythm.

  • Temperature compensation is an important characteristic of biological clocks.
  • In Neurospora crassa, the FRQ protein regulates the transcription of the frequency (frq) gene through negative feedback.
  • The stability of FRQ protein influences both the period length of the circadian rhythm and its temperature compensation.
  • Experimental measurements of FRQ protein stabilities in frq mutants at 20 degrees C and 25 degrees C align with earlier model predictions.
  • The partial loss of temperature compensation in frq7 and frq(S513I) mutants can be explained using the Goodwin oscillator model when activation energies for FRQ degradation are included.

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