Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

Feb 7, 2018Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Link Between a Common FTO Gene Variant and Obesity in Kuwait: A Public Health Issue?

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Abstract

The A allele of the FTO gene polymorphism rs9939609 is associated with an increase in body mass index (BMI) by an average of 1.21 units.

The A allele is linked to a higher likelihood of being overweight or obese, with an odds ratio of 1.47.
Linear regression analysis indicates that the A allele significantly contributes to BMI increases in Kuwaiti adults.
No significant association was found between the FTO variant and various cardiometabolic traits.
The results align with findings from other populations, suggesting a consistent genetic influence on obesity.

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OBJECTIVE: To investigate the effect of the common fat mass and obesity-associated (FTO) gene polymorphism rs9939609 on body mass index (BMI) in one of the most obese populations worldwide.

SUBJECTS AND METHODS: Genotypic data for FTO rs9939609 were available for 1,034 unrelated Kuwaiti adults obtained from Kuwait's Dasman Diabetes Institute and Kuwait University. The association between the FTO polymorphism with BMI as continuous and categorical (normal BMI [< 25] vs. overweight/obese [> 25]) variables was analyzed using both linear and logistic regression models, respectively, with the assumption of both dominant and additive genetic models performed using the SNPassoc package from R statistics.

RESULTS: The A allele was associated with increased BMI (β = 1.21; 95% CI = 0.16-2.26; p = 0.023). In concordance, the categorical BMI (normal vs. overweight/obese) also showed a significant association between the A allele and overweight/obesity (OR = 1.47; 95% CI = 1.01-2.12; p = 0.041). However, no association between the FTO variant was observed with cardiometabolic traits.

CONCLUSION: We observed an association between the common FTO rs9939609 polymorphism and increased BMI (overweight/obesity) in Kuwaiti adults, which is consistent with previous research in other populations. Our findings encourage further investigation of genetic variants to elucidate the mechanisms involved in the development of obesity in such an obesogenic population.

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Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

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