Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension

Jul 16, 2013Cardiovascular diabetology

How FTO and MC4R gene variants relate to obesity, type 2 diabetes, and blood pressure in people with high blood pressure

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Abstract

Rare allele frequencies were 0.40 for FTO rs9939609 and 0.18 for MC4R rs17782313 among 217 hypertensive individuals.

FTO rs9939609 and MC4R rs17782313 are positively associated with body mass index (BMI) in the overall sample.
Neck circumference is associated with the FTO genotype in both men and women and with the MC4R genotype in women.
In men, MC4R rs17782313 shows a negative association with diastolic blood pressure, with measurements of 90.1 ±12.2 for TT and 83.2 ±12.1 for TC/CC.
A borderline association between MC4R rs17782313 and systolic blood pressure is noted in men after adjusting for age and BMI.

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BACKGROUND: Genetic variants of the FTO gene rs9939609 A/T and the MC4R gene rs17782313 C/T have been associated with obesity. Individuals with mutations in MC4R gene have lower blood pressure (BP), independently of obesity. This study aimed to investigate the association of FTO rs9939609 and MC4R rs17782313 with anthropometric indexes, BP, and type 2 diabetes mellitus among hypertensive patients.

METHODS: We genotyped 217 individuals (86 men and 131 women) with hypertension (systolic or diastolic BP ≥ 140/90 mmHg or using antihypertensive drugs). Diabetes mellitus was diagnosed according to the American Diabetes Association criteria. Waist and neck circumferences (cm), Body Adiposity Index (BAI,%), Lipid Accumulation Product Index (LAP, cm.mmol.l) and body mass index (BMI, kg/m²) were analyzed using analysis of covariance or modified Poisson's regression.

RESULTS: Rare allele frequencies were 0.40 for A for FTO rs9939609 and 0.18 for C for MC4R rs17782313. A positive association of FTO rs9939609 and MC4R rs17782313 with BMI was observed in the overall sample. Among men and women, neck circumference was associated with the FTO genotype and, for women, MC4R genotype. In contrast, in men we found a negative association of MC4R rs17782313 with diastolic BP (TT 90.1 ±12.2, TC/CC 83.2 ±12.1; P = 0.03) and borderline association for systolic BP after controlling for age and BMI.

CONCLUSIONS: Common genetic variants of FTO rs9939609 have positive associations with BMI and neck circumference and MC4R rs17782313 in women, but a negative association with diastolic and mean blood pressure in men with hypertension.

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Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension

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