Cardiovascular journal of Africa

How two common gene variants together relate to higher nighttime blood pressure in Chinese Han people

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Updated

Abstract

The A allele of FTO rs9939609 and the C allele of MC4R rs17782313 are associated with increased nocturnal blood pressure, with odds ratios of 1.37 and 1.69, respectively.

  • Participants carrying both the A and C alleles exhibited significantly higher nocturnal blood pressure compared to those without these risk alleles.
  • No significant association was found between FTO or MC4R genes and daytime hypertension in this Chinese population.
  • The combined effects of the rs9939609 and rs17782313 variants on nocturnal blood pressure were significant.

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