Combined effects of FTO rs9939609 and MC4R rs17782313 on elevated nocturnal blood pressure in the Chinese Han population

Sep 2, 2015Cardiovascular journal of Africa

How two common gene variants together relate to higher nighttime blood pressure in Chinese Han people

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Abstract

The A allele of FTO rs9939609 and the C allele of MC4R rs17782313 are associated with increased nocturnal blood pressure, with odds ratios of 1.37 and 1.69, respectively.

  • Participants carrying both the A and C alleles exhibited significantly higher nocturnal blood pressure compared to those without these risk alleles.
  • No significant association was found between FTO or MC4R genes and daytime hypertension in this Chinese population.
  • The combined effects of the rs9939609 and rs17782313 variants on nocturnal blood pressure were significant.

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