Relationships between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men – a preliminary study

Dec 7, 2016Clinical interventions in aging

Links between common gene variants and metabolic or hormonal problems in middle-aged and older men: a preliminary study

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Abstract

In a study of 272 Caucasian men aged 50-75, higher levels of total cholesterol and LDL cholesterol were linked to the rs9939609 genetic polymorphism.

No significant associations were found between the analyzed genetic polymorphisms and the presence of , type 2 diabetes, hypertension, or obesity.
Men with the rs9939609 polymorphism exhibited higher total cholesterol and LDL cholesterol levels.
A lower waist circumference was associated with the rs17782313 polymorphism under the recessive inheritance model.
The examined genetic polymorphisms may have minimal effects on metabolic disorders and no effects on androgen-related disorders in the studied population.

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PURPOSE: Metabolic disorders, including , obesity, and lipid disorders, may be related to genetic factors. Metabolic disorders are associated with decreased TS levels in aging men. The aim of this study was to evaluate the relationship betweenrs9939609,rs17782313, andrs1801282 polymorphisms and the presence of MetS and its components, the concurrent lipid disorders, as well as sex hormone concentrations. FTO MC4R PPARγ

SUBJECTS AND METHODS: This study involved 272 men of Caucasian descent aged 50-75 years. Lipid profile, including TCh, LDL, HDL, and TG, was evaluated by spectrophotometric method. Anthropometric measurements concerned WC and blood pressure. MetS was diagnosed according to the criteria of the IDF. Sex hormone profile, including TST, FTS, E, DHEAS, and SHBG, was examined using enzyme-linked immunosorbent assay. Polymorphisms within,, andgenes were identified using polymerase chain reaction-restriction fragments length polymorphism. 2FTO MC4R PPARγ

RESULTS: This study did not show links between the analyzed genetic polymorphisms and the presence of MetS, T2DM, HT, and obesity. However, higher concentrations of TCh and LDL were found in men with thers9939609 polymorphism in the recessive mode of inheritance (=0.03 and=0.05, respectively). Lower WC was found to be associated withrs17782313 gene inherited in the same model (=0.005). FTO P P MC4R P

CONCLUSION: rs9939609,rs17782313, andrs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men. FTO MC4R PPARγ

Key numbers

153.04 mg/dL

Higher LDL Concentration

LDL levels in TT genotype vs. AA + AT genotypes

223.07 mg/dL

Higher Total Cholesterol Level

Total cholesterol levels in TT genotype vs. AA + AT genotypes

99.77 cm

Lower Waist Circumference

Waist circumference in TT genotype vs. CC + CT genotypes

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Relationships between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men – a preliminary study

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