Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (PPAR-γ), the fat mass and obesity-associated (FTO), and the melanocortin-4 receptor (MC4R) genes

Jan 10, 2018Aging

Links between metabolic syndrome factors and gene variations related to fat regulation and appetite

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Abstract

A statistically significant relationship was found between the A/A genotype of the rs9939609 polymorphism and glycemia in women aged 45-60.

The A/A genotype is associated with an increased risk of hyperglycemia.
A trend towards significance was observed for the C/G genotype, which could be linked to hypertriglyceridemia.
The C/C genotype is statistically associated with an increase in blood pressure.
Genetic predisposition may play a role in MetS-related abnormalities, though not all associations are clearly demonstrated.

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INTRODUCTION: Metabolic syndrome (MetS) is regarded as a set of abnormalities, increasing the risk of serious functioning disorders. It can develop as a result of genetic predisposition.

AIM: The aim of this study was to establish associations between MetS-related abnormalities and thers1801282,rs9939609, andrs17782313 polymorphisms. PPAR-γ FTO MC4R

MATERIAL AND METHODS: The study involved 425 women aged 45-60 years. The participants were surveyed and subjected to anthropometric, biochemical and genetic analysis.

RESULTS: In the recessive inheritance model for thepolymorphism, a statistically significant relationship was demonstrated between the A/A genotype and glycemia. The results obtained in the codominant and overdominant models for thepolymorphism showed a tendency to statistical significance (the C/G genotype inclined to hypertriglyceridemia), and were statistically significant in the codominant, dominant, and recessive models (the C/C genotype predisposed to increased blood pressure). FTO PPAR-y

CONCLUSIONS: 1. MetS-related abnormalities can be genetically determined, however only some of these relationships can be demonstrated due to the categorical division of symptoms according to the IDF criteria from 2009. 2. The A/A genotype of thers9939609 polymorphism increases the risk of hyperglycemia, and the C/C genotype of thers1801282 variant entails elevated blood pressure in 45-60-year-old women. FTO PPAR-γ

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Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (PPAR-γ), the fat mass and obesity-associated (FTO), and the melanocortin-4 receptor (MC4R) genes

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