GeneNov 21, 2017

FTO gene variant linked to long-term diabetes complications in Czech people

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 29, 2026

Abstract

The frequency of the GG genotype for the FTO gene was 25.4% in T2DM patients compared to 16.7% in healthy controls.

The FTO gene variant rs17817449 is linked to susceptibility to type 2 diabetes mellitus (T2DM) in the Czech-Slavonic population.
No significant difference in FTO genotype frequency was found between type 1 diabetes mellitus (T1DM) patients and controls.
T1DM patients with the GG genotype have an increased risk of developing diabetic nephropathy compared to TT homozygotes.
T2DM patients with the GG genotype or G carriers also show a higher risk of diabetic nephropathy compared to TT homozygotes.
The FTO genotype is linked to the development of diabetic neuropathy in T2DM patients but not in T1DM patients.
No association was found between the FTO genotype and the development of diabetic retinopathy.

Simplified

BACKGROUND: Genome-wide association studies have resulted in the identification of the FTO gene as an important genetic determinant of diabetes mellitus. The aim of this study was to confirm the role of this gene in the development of DM in the Czech-Slavonic population and to analyse whether this gene is associated with common DM complications.

METHODS: Two groups of patients (814 with T1DM and 848 with T2DM) and a group of healthy controls (2339 individuals) - both of Czech origin - were genotyped for the FTO rs17817449 SNP. ANOVA and logistic regression were used for the statistical evaluations.

RESULTS: The frequency of the GG genotype was significantly higher in T2DM (25.4% vs. 16.7%, P<0.0005) but not in T1DM patients (19.3% vs. 16.7%, P=0.20) than in controls. The increased risk of development of diabetic nephropathy was observed both for T1DM patients (GG vs. TT homozygotes, P<0.01) and T2DM patients (G carriers vs. TT homozygotes, P<0.05). FTO genotype predicted the development of diabetic neuropathy (GG vs. TT comparison; P<0.01) in the T2DM patients only. No association between FTO genotype and development of retinopathy was detected. All presented values are after adjustment for age, sex, BMI and duration of diabetes.

CONCLUSIONS: We confirm the association between the FTO rs17817449 SNP and susceptibility to T2DM in the Czech-Slavonic population. The same variant is associated with a spectrum of chronic complications in both types of diabetes.

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FTO gene variant linked to long-term diabetes complications in Czech people

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