Journal of the American Chemical Society

Lipid Nanoparticles Made from Furan for Delivering mRNA to the Brain and Spinal Cord

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Updated

Abstract

Tetrahydrofuran-derived lipid nanoparticles achieved significantly higher mRNA delivery efficiency to the brain compared to FDA-approved SM102 lipid nanoparticles.

  • Furan-derived lipids were designed to improve mRNA delivery to the central nervous system.
  • Lipid nanoparticles formulated with four-acetal-tail mono-THF-derived lipid F10T5 and four-acetal-tail di-THF-derived lipid F11T6 showed exceptional performance.
  • These lipid nanoparticles bypassed the blood-brain barrier through the lymphatic pathway.
  • The nanoparticles traveled from deep cervical lymph nodes to the meninges before entering brain cells.
  • This approach may provide new strategies for delivering mRNA therapies to the brain.

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