Furan-Derived Lipid Nanoparticles for Transporting mRNA to the Central Nervous System

Apr 30, 2025Journal of the American Chemical Society

Lipid Nanoparticles Made from Furan for Delivering mRNA to the Brain and Spinal Cord

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Abstract

Tetrahydrofuran-derived lipid nanoparticles achieved significantly higher mRNA delivery efficiency to the brain compared to FDA-approved SM102 lipid nanoparticles.

  • Furan-derived lipids were designed to improve mRNA delivery to the central nervous system.
  • Lipid nanoparticles formulated with four-acetal-tail mono-THF-derived lipid F10T5 and four-acetal-tail di-THF-derived lipid F11T6 showed exceptional performance.
  • These lipid nanoparticles bypassed the blood-brain barrier through the lymphatic pathway.
  • The nanoparticles traveled from deep cervical lymph nodes to the meninges before entering brain cells.
  • This approach may provide new strategies for delivering mRNA therapies to the brain.

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