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International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
Naming, types, and drug effects of melatonin receptors that work through G proteins
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Abstract
Melatonin concentrations in circulation follow a circadian rhythm, peaking at night.
- Melatonin is synthesized mainly in the pineal gland and retina, with additional production in various tissues.
- High nighttime levels of melatonin provide timing cues to target tissues that have melatonin receptors.
- Melatonin receptors, specifically MT(1) and MT(2), may influence daily and seasonal rhythms of physiology and behavior.
- These receptors are potential therapeutic targets for conditions such as insomnia, depression, cardiovascular diseases, and cancer.
- Current research focuses on characterizing these receptors and developing ligands for treating multiple illnesses.
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