Galangin reduces UVB-caused skin aging by activating a protein that controls cell cleaning

Ultraviolet B (UVB) irradiation is a major contributor to skin photoaging.

• UVB exposure promotes oxidative stress in skin cells.
• It leads to degradation of the extracellular matrix, which is vital for skin structure.
• Cellular senescence, the process where cells lose the ability to divide, is increased by UVB irradiation.
• Sirtuin 1 (SIRT1) plays a crucial role in maintaining cellular health and regulating autophagy.
• Phytochemical-based interventions may target SIRT1 to mitigate effects of UVB on skin aging.

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