Full text is available at the source.
Gastric vagal afferent modulation by leptin is influenced by food intake status
Leptin's effect on stomach nerve signals depends on whether food has been eaten
AI simplified
Abstract
Leptin potentiated vagal mucosal afferent responses to tactile stimuli in female C57BL/6 mice fed a standard diet.
- Leptin may be secreted from gastric epithelial cells and influences vagal afferent signaling.
- In a high-fat diet or after fasting, the potentiation of mucosal afferents by leptin was lost.
- Leptin receptor expression decreased in the cell bodies of gastric mucosal afferents after fasting or diet-induced obesity.
- In diet-induced obese mice, anatomical vagal innervation of the gastric mucosa was reduced.
- Leptin inhibited responses to gastric distension in tension receptors after fasting or high-fat feeding.
- The inhibition of tension receptor responses by leptin involved specific signaling pathways, including activation of large-conductance calcium-activated potassium channels.
AI simplified