A total of 35 studies were identified that evaluated the effects of (GQD) and its constituents on diabetes management.
GQD, berberine, and puerarin may improve blood glucose control in individuals with diabetes mellitus.
GQD and berberine could significantly reduce total cholesterol, total triglycerides, and low-density lipoprotein levels.
Intervention with GQD and berberine may also increase high-density lipoprotein levels.
The efficacy and safety of GQD and its constituents for managing remain debated.
High-quality primary studies are needed to provide a clearer understanding of the effects of GQD and its main components.
Simplified
Currently, an increasing number of individuals diagnosed with diabetes mellitus (DM) are opting for combined functional substances in edible plant products, like herbal prescription or traditional Chinese medicine (TCM), to enhance the efficacy of blood glucose and lipid profile control. Among various TCM-included treatments available, (GQD) is frequently utilized. Nevertheless, the efficacy and safety of GQD and its main constituents (berberine, puerarin, etc.) in managing (GLMD) in DM remain under considerable debate. This overview aims to provide a concise summary of the key findings from systematic review and meta-analysis (SRMAs) on GQD and its main constituents for GLMD in DM, while also assessing the methodological quality of these reviews. A comprehensive search of online databases was conducted with no language restrictions, covering the period from inception to February 20th, 2025. The methodological quality, risk of bias, and strength of evidence of those included SRMAs were accessed. Overlapping randomized controlled trials (RCTs) were excluded, and the results of included meta-analysis were summarized. After screening, 35 studies matching the inclusion criteria were identified. The current evidence indicated that GQD, berberine, and puerarin appeared to be effective in improving the anti-diabetes role. As for blood lipid profile, it is indicated that GQD and berberine intervention could effectively reduce total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL-c) and increase high-density lipoprotein (HDL-c). Consequently, further high-quality primary studies are imperative to establish a more conclusive understanding of GQD and its main constituents for GLMD in DM.
Key numbers
−1.19
FBG Reduction
Mean difference in fasting blood glucose levels after intervention
−0.50
TC Reduction
Mean difference in total cholesterol levels after intervention
0.18
HDL-c Increase
Mean difference in high-density lipoprotein cholesterol levels after intervention
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Declarations. Ethics approval and consent to participate: N/A. Consent for publication: N/A. Competing interests: The authors declare that they have no competing interests.
