Full text is available at the source.
Abstract
Gene expression and metabolite levels were profiled in 335 females over 8 years, revealing changes in 5061 genes and 181 metabolites.
- Individual trajectories of gene and metabolite levels often diverged from overall population trends.
- Longitudinally variable genes exhibited specificity to particular cell types and were linked to pathways relevant to aging.
- Factors such as genetics, circadian rhythm, seasonality, and exposure to environmental pollutants influenced longitudinal changes.
- Integrative analyses highlighted both stable and time-variable connections between different biological measurements.
Simplified