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Abstract
Clinical trials are investigating gene therapy approaches for retinal degenerative diseases, which contribute significantly to vision loss globally.
- Inherited and complex retinal diseases, like retinitis pigmentosa and glaucoma, have substantial genetic diversity and complicated mechanisms.
- Current treatments for these conditions are limited, lacking safe and effective disease-modifying options.
- Various ongoing clinical trials are exploring gene-specific and gene-agnostic therapies, including the use of viral vectors for gene delivery.
- Different delivery methods, such as subretinal and intravitreal, are being tested for their effectiveness in treating these eye diseases.
- Initial results from clinical trials indicate potential benefits of gene therapy, though long-term data is needed to fully evaluate efficacy and safety.
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