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Abstract
Non-viral gene delivery systems may offer safer alternatives to viral vectors in gene therapy.
- Non-viral platforms include lipid-based nanoparticles, polymers, dendrimers, inorganic nanocarriers, and hybrid systems.
- These systems are associated with customizable properties and scalable manufacturing.
- Reduced risk of adverse immune responses is a noted advantage of non-viral vectors.
- Key parameters influencing effectiveness include cellular uptake, endosomal escape, nuclear localization, and transfection efficiency.
- Recent preclinical and clinical studies show promising outcomes for non-viral gene delivery in various diseases, particularly cancers.
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